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Scientific
Mission

Artist´s view of CMF (© Dennis Luck)

The molecular composition of systemic biofluids of living organisms is a sensitive indicator of their physiological states, useful for disease detection. The capability of observing signatures of miniscule changes in concentration of a wide variety of molecules of liquid biopsies (blood plasma and serum) is thus crucial for advancing systems biology and medical diagnostics.

Molecules of naïve organic samples are illuminated by ultrashort laser pulses. The abruptly excited molecules emit light at characteristic frequencies in the wake of the excitation. The electric field of this molecular signal is detected with femtosecond-attosecond resolution by using world-leading ultrafast laser technology. The new approach – field-resolved laser molecular fingerprinting – suits for detecting simultaneous, correlated changes in concentration of a wide variety of molecules across all types relevant to biological systems: proteins, lipids, carbohydrates, and amino acids. The resultant molecular fingerprint holds promise, possibly in combination with other biomarking approaches, for improving the specificity and sensitivity of molecular disease detection.

CMF pursues the development, testing and validation of laser molecular fingerprinting for next-generation blood-based diagnostics with large-scale clinical samplings in cooperation with major health-care institutions in Hungary and abroad. This mission is driven by the vision of a reliable, cost-effective, high-throughput approach for:

  • populational health monitoring,
  • disease detection.

The initial focus is on detection of cancer and cardio-vascular disease conditions. To this end, an international collaborative network of clinical and research centers is being established. Long-term preservation of the invaluable blood samples collected for the above goals will be performed at cryogenic conditions in a dedicated CMF biobank. Standardized workflows are used for sample collection as well as for secure collection and management of harmonized clinical information in a database system designed for handling big data, among a highly professional quality control system with an overall thorough adherence to the GDPR provisions. Machine learning algorithms will be applied for sample classification based on their laser molecular fingerprints and established biomarkers.


The aim

Development of laser molecular fingerprinting for next-generation molecular diagnostics of blood, aiming at health monitoring and disease detection.

How?

A drop of blood plasma is exposed to ultrashort laser light and the light waves emitted by the excited molecules of the sample are directly detected with femtosecond-attosecond laser techniques.

Funded by

Hungarian Ministry of Innovation and Technology.

News

(© Thorsten Naeser)
November 4, 2020
Let there be light: Laser Development and Technology Team forms at CMF

When it comes to disease detection and health monitoring with field-resolved molecular fingerprinting, turning our vision into reality requires dedicated technological development at the forefront of our scientific research.

November 4, 2020
Let there be light: Laser Development and Technology Team forms at CMF

When it comes to disease detection and health monitoring with field-resolved molecular fingerprinting, turning our vision into reality requires dedicated technological development at the forefront of our scientific research. It starts from the development of new mid-infrared laser sources via advancing sample handling and detection technologies and goes toward finding optimal data acquisition and processing strategies. Over the last couple of months, a new team has formed at CMF with the particular goal to tackle these technical and scientific challenges. In close collaboration, the CMF laser development and technology team in Garching (Germany) is joining forces with LMU laser scientists to combine all technological advances in a one of a kind prototype device for molecular fingerprinting. Once the laser laboratory of CMF will open its gates in Budapest, this instrument will be fundamental to be used in blood sample analysis. Currently, the CMF team headed by Dr. Alexander Weigel is moving frontiers in laser development and solving experimental challenges towards that end.

October 28, 2020
Strengthening the team: Viola Zoka

We would like to wish a warm welcome to a new colleague: Since October 2020, the research group around Dr. Mihaela Žigman has been supported by Viola Zóka, a new medical-technical assistant!

October 28, 2020
Strengthening the team: Viola Zoka

We would like to wish a warm welcome to a new colleague: Since October 2020, the research group around Dr. Mihaela Žigman has been supported by Viola Zóka, a new medical-technical assistant!

The young Hungarian completed Bachelor of Science in Chemistry. She had developed her passion for chemistry early on and intensified it by her professional experience in a laboratory in Nagykanizsa, Hidrofilt Ltd. Hungary, where she performed analytical chemistry of water samples. When Viola heard about newly developing infrared molecular fingerprinting to analyze way more complex human blood samples that she was used to, she applied for a job at the Center for Molecular Fingerprinting (CMF). CMF is strongly collaborating with the Laser Physics department of the Ludwig Maximilians University (LMU) Munich and prior to having its own laboratories built and established in Hungary, the samples from the clinical studies lead by CMF will be analyzed at the LMU. And Viola made a move from Hungary to Germany to start her new professional life at the Garching Research Center and directly fuel the CMF research goals from there. Together with laser scientist and molecular biologists, Viola will analyze blood samples for their molecular composition using infrared spectroscopy - something that everyone is very much excited about!

March 11, 2020
Sample storage at its best

CMF’s strategic partner, the Ludwig-Maximilians-University (LMU) in Munich, Germany, just installed an automated biobanking system for…

March 11, 2020
Sample storage at its best

CMF’s strategic partner, the Ludwig-Maximilians-University (LMU) in Munich, Germany, just installed an automated biobanking system for sample storage at temperatures below minus 150°C. What is this good for? Under these very low temperatures - so called “cryogenic” conditions in the atmosphere above liquid nitrogen - human samples, such as blood plasma or actually any biological tissues, can be kept for several years, decades without sample deterioration. It assures that valuable human materials collected in frame of clinical studies can be used in long term and thus enables researchers to analyze these with molecular fingerprinting techniques most efficiently. Such an automated cryogenic system is made of large tightly sealed tank that is capable to store up to 60,000 samples. The system is further equipped with a robotic arm that can pick individual tubes automatically, such that the samples are kept and handled well below minus 100 °C at all times.

This installation has a direct impact for the future of the joint CMF-LMU research aims. On the one hand the two institutions will be conducting joint clinical studies. On the other, LMU biobanking system also serves as a test case for the CMF’s envisioned own biorepository, to be established in Budapest.

Thus, CMF is getting familiar with the best way to store most valuable biological materials for the years of research to come!

January 07, 2020
Field-resolved infrared spectroscopy of biological systems

In cooperation between the Laboratory of Attosecond Physics at the Max Planck Institute of Quantum Optics…

January 07, 2020
Field-resolved infrared spectroscopy of biological systems

In cooperation between the Laboratory of Attosecond Physics at the Max Planck Institute of Quantum Optics and the Centre for Advanced Laser Applications of the Ludwig-Maximilians-Universität München, the King Saud University Riad and the Center for Molecular Fingerprinting (Budapest, Hungary), we have developed a molecular spectroscopy technique that overcomes long-standing limitations of traditional techniques, like Fourier-transform infrared spectroscopy, as described in our recent publication. A powerful femtosecond laser delivers 28 million pulses per second, with highly repeatable waveforms, comprising merely a few infrared-electric-field oscillations. Transmitting these pulses through a complex, molecular sample synchronously excites infrared-active vibrations of molecular bonds, each at its own eigenfrequency. The signals emitted by the vibrationally-excited molecules in the wake of the impulsive excitation coherently add up to a ‘molecular fingerprint’ characteristic of the sample’s molecular composition.

In contrast to traditional spectroscopies, where the entire response of the sample to an infrared excitation hits the detector(s), in field-resolved spectroscopy sub-optical-cycle portions of the time-domain fingerprint field are sequentially carved out by means of nonlinear optics. This dramatically reduces any infrared background on the measured signals, including the noise originating from the excitation and thermal background. This conceptional advance results in an unprecedented detection sensitivity and dynamic range.

We have also demonstrated first biological applications that have so far been beyond the reach of infrared vibrational spectroscopies. These applications include first high-signal-to-noise ratio infrared transmission measurements of living biological tissue and fingerprinting of liquid biopsies with sub-µg/ml sensitivity. Thus, field-resolved spectroscopy promises improved molecular sensitivity and molecular coverage for probing complex, real-world biological and medical settings.

December 16, 2019
Honorary membership for Prof. Krausz

Prof. Ferenc Krausz has recieved the honorary membership of the Roland Eötvös Physical Society, Budapest. After…

December 16, 2019
Honorary membership for Prof. Krausz

Prof. Ferenc Krausz has recieved the honorary membership of the Roland Eötvös Physical Society, Budapest. After receiving the membership the laser physicist of the Ludwig-Maximilians University München and the Max-Planck-Institute of Quantum Optics held an lecture about how attosecond science technologies can in the future contribute to a new way of finding molecules in human biofluids like blood. This may path the way for medical applications to detect diseases by analyzing so called molecular fingerprints with the help of strong laser light pulses.

            Team

Prof. Dr. Ferenc Krausz

Scientific Director, CEO

krausz@cmf.science

László Vastag, MD

Managing Director

vastag@mukkozpont.hu

Dr. Mihaela Žigman

Research Director

zigman@mukkozpont.hu

Dr. Frank Fleischmann

Advisor – Biological Laboratories

fleischmann@mukkozpont.hu

Eszter Tuboly PhD

Biobank Manager

tuboly@mukkozpont.hu

Márton Görög

Leader Data Scientist

gorog@mukkozpont.hu

Viola Zóka

Medical technical assistant

zoka@mukkozpont.hu

Zsuzsa Uti

L4L Project Coordinator

uti@mukkozpont.hu

Dr. Alexander Weigel

Chief Laser Scientist

weigel@mukkozpont.hu

Patrik Karandušovský

Computer Scientist

karandusovsky@mukkozpont.hu

Aleksandar Sebesta

Laser Engineer

sebesta@mukkozpont.hu

Maciej Kowalczyk

Laser Scientist

kowalczyk@mukkozpont.hu

Shizhen Qu

Laser Scientist

qu@mukkozpont.hu

Christina Hofer

Nonlinear Optics Scientist

hofer@mukkozpont.hu

Partners

(© Thorsten Naeser)

CMF seeks extending the above network of long-term strategic partners with clinical centers and other healthcare providers across Hungary and abroad for the pursuit of its mission.

            Join us

Individuals interested in joining a highly-motivated team dedicated to the pursuit of the grand goals of CMF are invited to apply for the following open positions:

25th November, 2020

Postdoc: Physicist with Background in Nonlinear Optics

At the Center for Molecular Fingerprinting, we combine cutting-edge femtosecond laser technologies with novel molecular fingerprinting techniques to advance a new type of mid-infrared spectroscopy on the electric-field level. The novel systems are developed and utilized by a highly interdisciplinary team of physicists, data scientists, biologists and clinical personal to identify, via minuscule variations in the infrared response, medical conditions such as cancer in body liquid samples.

The successful candidate will work together with scientists and technicians at the CMF and the Joint LMU-MPQ Laboratory for Attosecond Physics in Garching, Germany to develop next-generation instruments based on bright, coherent, broadband mid-Infrared sources and field-resolved detection. The goal for this position is to develop coherent field-resolved infrared metrology with multi-octave spectral coverage and unprecedented detection sensitivity. The duration of the position is initially 2 years, with the possibility of extension. For the first two years the place of work will be predominantly at the LAP in Garching, Germany.

Responsibilities:

  • Development of electric-field-resolved mid-infrared metrology
  • Reaching unprecedented spectral bandwidth and sensitivity with coherent mid-IR detection
  • Development of the detection technology for the next-generation instruments for large-scale health monitoring and desease detection with mid-infrared fingerprinting
  • Presentation and publication of scientific output

Qualifications and Skills:

  • PhD in physics or a related discipline
  • Experience with ultrafast lasers and nonlinear optics
  • Ideally, experience with infrared and/or nonlinear spectroscopies
  • Ideally, experience signal processing and programming (for example with Labview)
  • Interest in interdisciplinary work with interface to biomedical applications
  • Good command of the English language

What we can offer:

  • full-time semi office-based job
  • competitive salary & benefits
  • motivated local and international team
  • development opportunity

Please send a brief cover letter explaining your interest in the position, your CV and contact information of two references to Dr. Alexander Weigel (weigel@mukkozpont.hu).

25th November, 2020

Clinical Research Associate

Task:

You have the opportunity to join our journey in the most unique state-funded research initiated by world-famous researchers with the involvement of renowned national and international academic partners. As a Clinical Research Associate you will take on the management of interventional human research project(s) plus potentially get involved in Lead CRA/project manager role for an expanding team.

Roles:

  • Full ownership of study management
    • investigators & sites - responsibility for the successful management of all site-related activities from feasibility through maintenance till close-out including Investigator relationship management, document management, site stock monitoring, sample shipment, issue detection, reporting, resolution
    • compliance - ensuring SOP and regulatory compliance for site activities as well as data integrity and validity, assistance during audit/inspection
    • regulatory and ethics – submission package compilation, deficiency response, amendment submission
    • contract and payment – contract negotiation, payment preparation
    • vendors – involvement in specification, procurement, and commissioning of supplies

Required attributes:

  • Experience in investigator site management – either in clinical pharmacology trials, or preferably interventional human research trials (i.e. trials w/o investigational drug administration) including feasibility, site initiation, monitoring and close-out, recruitment support, source data verification, query management, plus appropriate document management
  • Regulatory knowledge – familiar with local regulatory requirements
  • Life science background – a minimum of master’s level degree in life sciences
  • Language knowledge - fluency in Hungarian and English including technical terms
  • IT – strong user-level knowledge of MS Office
  • Interpersonal skills - proactive, enthusiastic team player
  • Flexibility – ability to tolerate a fast-paced working environment, rapidly changing circumstances

A strong plus, if you:

  • hold a medical doctor degree
  • hold a PhD
  • have experience in process and/or SOP development
  • can demonstrate a project management skill
  • own a car and accept a car allowance

What we can offer:

  • full-time semi office-based job
  • competitive salary & benefits
  • motivated local and international team
  • development opportunity

Please send a brief cover letter explaining your interest in the position and your professional CV to Eszter Márton-Szűcs (martonszucs@mukkozpont.hu)

November 25, 2020

Chief Clinical Research Manager

If you:

  • feel to have more potential than treadmilling the same path from study to study
  • fed up with managing 6 studies with less than 100 subjects involved
  • like to be part of a project of historical importance with unprecedented magnitude
  • can exhibit creative & strategic thinking
  • have more interest in science and the future vs. dividends for the shareholders
THEN APPLY FOR OUR POSITION!

Task:

Our company is setting up a unique longitudinal human research study with the participation of 15,000 individuals in Hungary to validate a groundbreaking diagnostic procedure that could be a game changer in the field of health monitoring. As a Chief Clinical Research Manager you will be responsible for leading the full scale interventional human research program (no IP) including setup of the strategy, recruiting the team and leading them to success.

Roles:

  • Full leadership and ownership of multiple research studies
    • setup of research strategy
    • recruitment and subsequent management of clinical team
    • leading and overseeing:
      • regulatory activities, compliance
      • site management
      • contracts and payment
      • vendors

Required attributes:

  • Experience - clinical research project management and/or team lead
  • Regulatory - good oversight of regulatory activities
  • Life science background – a minimum of master’s level degree in life sciences
  • Language knowledge - fluency in Hungarian and English including technical terms
  • IT – strong user-level knowledge of MS Office
  • Interpersonal skills - proactive, enthusiastic team player
  • Flexibility – tolerating a fast-paced working environment, rapidly changing circumstances

A strong plus, if you:

  • hold a medical doctor degree
  • hold a PhD
  • have experience in process and/or SOP development

What we can offer:

  • full-time semi office-based job
  • competitive salary & benefits
  • motivated local and international team
  • development opportunity
  • make history

Please send a brief cover letter explaining your interest in the position and your professional CV to Eszter Márton-Szűcs (martonszucs@mukkozpont.hu)

9th June, 2020

Electrical Engineer

At the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) we combine cutting-edge femtosecond laser technologies [1-3] with novel molecular fingerprinting techniques [4,5] to advance a new type of mid-infrared spectroscopy on the electric-field level. The novel systems are developed and utilized by a highly interdisciplinary team of physicists, data scientists, biologists and clinical personal to identify, via minuscule variations in the infrared response, medical conditions such as cancer in body liquid samples.

The successful candidate will work together with scientists and technicians at the CMF and the Joint LMU-MPQ Laboratory for Attosecond Physics (LAP, attoworld.de) in Garching (Germany) to develop next-generation instruments of laser-based instrumentation for field-resolved detection. The goal for this position is to optimize photodetection, to precisely synchronize and stabilize multiple pulsed lasers, and signal acquisition with suitable microwave electronics. The duration of the position is initially 2 years, with the possibility of extension. For the first two years the place of work will be predominantly at the LAP in Garching (Germany).

Tasks:

  • Identify and implement low-noise, high-dynamic range photodection solutions for our instruments
  • Develop precise feedback loops for synchronization and stabilization of pulsed lasers
  • Generate and modify microwave signals for clocking low-noise, high-speed data acquisition
  • Develop the electric/electronic backbone for laser-based instrument prototypes.

Qualifications and Skills:

  • Master’s degree or equivalent in electrical engineering or a related technical discipline
  • Experience with ultra-sensitive photodetection, and minimizing detection noise
  • Experience with electronic signal generation and synchronization including PLLs
  • Experience with handling electrical signals in the microwave regime
  • Ideally, experience with FPGA programming
  • Interest in interdisciplinary work with interface to bio-medical applications
  • Good command of the English language
  • German language skills are advantageous

Please send a brief cover letter explaining your interest in the position, your CV and contact information of two references to Dr. Alexander Weigel (weigel@cmf.science).

[1] J. Zhang et al., Light Sci. Appl. 7, 17180 (2018).
[2] Q. Wang et al., Opt. Letters 44, 2566 (2019).
[3] N. Nagl et al., Opt. Letters 44, 2390 (2019).
[4] I. Pupeza et al., Nature Photon. 9, 721 (2015).
[5] I. Pupeza et al., Nature 577, 52 (2020).

9th June, 2020

Laser Engineer

At the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) we combine cutting-edge femtosecond laser technologies [1-3] with novel molecular fingerprinting techniques [4,5] to advance a new type of mid-infrared spectroscopy on the electric-field level. The novel systems are developed and utilized by a highly interdisciplinary team of physicists, data scientists, biologists and clinical personal to identify, via minuscule variations in the infrared response, medical conditions such as cancer in body liquid samples.

The successful candidate will work together with scientists and technicians at the CMF and the Joint LMU-MPQ Laboratory for Attosecond Physics (LAP, attoworld.de) in Garching (Germany) to develop next-generation instruments based on bright, coherent, broadband mid-Infrared sources and field-resolved detection. The goal for this position is to transform latest research results into a technically mature and reliable laser-based measurement system with unprecedented performance. The duration of the position is initially 2 years, with the possibility of extension. For the first two years the place of work will be predominantly at the LAP in Garching (Germany).

Tasks:

  • Development of laser system prototypes (including laser oscillators, amplifiers, compressors, conversion and detection modules), based on exiting research setups
  • Technical improvement of the laser systems to optimize for example stability, noise performance and user friendliness
  • Test and characterize laser and downstream module specifications and resolve potential problems
  • Instruct new team members in the usage of the laser and measurement systems

Qualifications and Skills:

  • Master’s degree or higher in physics or a related technical discipline
  • Experience with the setup and adjustment of optical systems
  • Strong self-motivation and the ability to solve problems independently
  • Experience with computer-aided technical drawings (e.g., Autodesk Inventor)
  • Ideally, experience with Labview, Python, or another programming language
  • Interest in interdisciplinary work with interface to bio-medical applications
  • Good command of the English language
  • German language skills are advantageous

Please send a brief cover letter explaining your interest in the position, your CV and contact information of two references to Dr. Alexander Weigel (weigel@cmf.science).

[1] J. Zhang et al., Light Sci. Appl. 7, 17180 (2018).
[2] Q. Wang et al., Opt. Letters 44, 2566 (2019).
[3] N. Nagl et al., Opt. Letters 44, 2390 (2019).
[4] I. Pupeza et al., Nature Photon. 9, 721 (2015).
[5] I. Pupeza et al., Nature 577, 52 (2020).

11th November, 2019

Database Specialist

We are seeking a suitable candidate for filling the position of a Database Specialist at the earliest possible date. The aim of the new collaborative project is to unite expertise in infrared laser physics, molecular fingerprinting on large-scale human biobanking to develop a research agenda that establishes the novel approach of laser-based infrared spectroscopy as a reliable tool for cancer diagnostics.

We seek a specialist that sets up databases, continuously improves and operates them to collect, manage, and analyze data from clinical trials and epidemiological studies dedicated to the disease detection using novel laser-based technologies. Independent databases will be established and applied, for clinical subject’s data, laboratory information, and management systems to develop and deliver high-quality clinical data for advancing the frontiers of disease detection.

Clinical studies for cancer detection suggest that the approach carries high potential with wide societal impact, already at the early stage of development. To further develop it, test its efficiency in combination with other state-of-the-art molecular approaches, as well as to validate it on large independent populations for real-world clinical problems.

Major tasks include

  • full responsibility for setting up, maintaining and advancing clinical and laboratory databases,
  • data management according to best practices in the field, as well as for documentation and training on data collection practices, query management and database procedures,
  • working with collaborators on data content requirements throughout the different steps of data management lifecycle,
  • contributing to protocol development, with focus on data management issues and cross- study data collection consistency,
  • contributing to the design of study specific clinical report forms (CRFs) and data management plans,

in close cooperation with colleagues specializing in clinical project management and data analysis.

Required qualifications and skills:

  • master’s degree, preferably in informatics, or information systems or related areas,
  • experience using (clinical) database setup and management,
  • ability of multi-tasking and building efficient working relationships with a wide variety of collaborators,
  • good command of English.

We offer:

  • a broad range of activities in a dynamically evolving second-to-none endeavour and professional environment with ample opportunities for improving professional skills and qualifications,
  • possibility of partially working from home, with base in Munich with frequent visits to Budapest,
  • full time, permanent position.

We are interested in filling the position as soon as possible and applications are continuously evaluated until the position is filled.

Please send a brief cover letter explaining your interest in the post, your CV and contact information of two references to László Vastag (vastag@mukkozpont.hu) and Dr. Mihaela Zigman (zigman@cmf.science).

25th November, 2020

Laser Technical Assistant

We are seeking a suitable candidate for filling the position of a Laser Technical Assistant at the earliest possible date. The aim of the new collaborative project is to unite expertise in infrared laser physics, molecular fingerprinting on large-scale human biobanking to develop a research agenda that establishes the novel approach of laser-based infrared spectroscopy as a reliable tool for cancer diagnostics.

At the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) we combine cutting-edge femtosecond laser technologies with novel molecular fingerprinting techniques to advance a new type of mid-infrared spectroscopy on the electric-field level. Our novel infrared molecular fingerprinting is developed and utilized by a highly interdisciplinary team of laser physicists, data scientists, biologists and clinical personal to identify medical conditions in samples of human bioliquids. The consortium provides a translational bridge between laser physics and clinical sciences. Its central goal is to demonstrate how a unique laser technology, that generates ultrashort light pulses, can be utilized for the early detection of diseases such as cancer.

The successful candidate will work together with scientists and technicians of the CMF and the Ludwig-Maximilians-Universität (LMU) (attoworld.de) in Garching (Germany) to develop next-generation instruments based on bright, coherent, broadband mid-Infrared sources and field-resolved detection. The goal for this position is to test the feasibility of coherent field-resolved infrared metrology with multi-octave spectral coverage and unprecedented detection sensitivity for infrared fingerprinting of blood-based human biofluids (https://www.lasers4life.de/). We are seeking a suitable candidate for filling the position of a Laser Technical Assistant to help performing high-throughput measurements and establishing electric-field infrared spectroscopy.

The candidate will work in a highly international and interdisciplinary team in direct collaboration with the biorepository, which stores and pre-processes the samples, laser technicians and scientist, which develop and maintain the laser systems, and data analysts

Major tasks include

  • Routine operation of our laser-based infrared spectrometers, consisting of femtosecond-laser oscillators, amplifiers, pulse compressors and electro-optical detection systems;
  • Regular quality control and documentation of the achieved laser parameters;
  • Maintenance and fine adjustment of optomechanical components as well as implementation of improvements of the laser systems;
  • Facilitating the routine analysis of clinical sample;
  • Instruct new team members on how to use the laser spectrometer;
  • Elaboration of SOPs for laser operation in cooperation with biomedical staff.

Required qualifications and skills:

  • Bachelor degree (or equivalent) in physics, physical engineering or electrical engineering or related fields;
  • Experience in setup and adjustment of optical systems
  • Good command of English (written and spoken) is a pre-required, command of German and / or Hungarian is advantageous;
  • Ability to work in an international environment;
  • User-level computer management skills;
  • Quick learning and good communication skills;
  • Ability to work independently after training;
  • High level of responsibility.

We offer:

  • A broad range of activities in a dynamically evolving second-to-none endeavour and professional environment;
  • Ample opportunities for improving professional skills and qualifications – including professional trainings and workshops;
  • Position is initially limited to two years with the possibility of an extension

We are interested in filling the positions as soon as possible and applications are continuously evaluated until the position is filled.

Please send a brief cover letter explaining your interest in the post and your CV to Dr. Mihaela Zigman (mihaela.zigman@lmu.de) and Marinus Huber (huber.marinus@physik.uni-muenchen.de).

25th September, 2020

Microfluidic Platform Researcher

We are seeking for candidates interested in development and implementation of microfluidic platforms that enable spatio-temporal control of microfluidic-chamber/cuvette flow through systems (microfluidic chips) and its integration with laser-based field-resolved spectroscopy.

Postdoctoral Researcher position: Development of microfluidic chips and cuvettes for the mid-infrared spectroscopic investigation of biological fluids and cells for medical purposes

In collaboration between the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) and the Ludwig-Maximilians-Universität (LMU) in Munich (www.attoworld.de/bird) we combine cutting-edge femtosecond laser technologies with novel molecular fingerprinting techniques to advance a new type of mid-infrared spectroscopy on the electric-field level. The consortium of highly interdisciplinary team of laser physicists, data scientists, molecular biologists and clinical personnel is focusing on demonstration how state-of-the-art laser-based field-resolved infrared spectroscopy (FRS) that generates ultrashort light pulses1, can be utilized for health monitoring and disease detection (https://www.lasers4life.de/).

We are seeking for candidates interested in development and implementation of microfluidic platforms that enable spatio-temporal control of microfluidic-chamber/cuvette flow through systems (microfluidic chips) and its integration with laser-based field-resolved spectroscopy.This will allow infrared spectroscopy to be effectively applied to specimens in aqueous environments or liquids to obtain label-free chemical information about the sample for the investigation of cells as well as human blood-based bioliquids. The goal is to support and further develop the following three projects:

1. Infrared fingerprinting of human blood-based bioliquids for disease detection;

2. Coupling of liquid chromatography to infrared spectroscopy to increase the specificity of the above-mentioned application;

3. High-throughput infrared measurements of cells (i.e. label-free flow-cytometry).

The workplace is at the Laboratory for Extreme Photonics (LEX Photonics; www.lex-photonics.de) of the LMU at the research campus Garching, north of Munich. The candidate will work in a highly international and interdisciplinary team in direct collaboration with laser scientists, engineers, developing the next generation laser-based infrared spectrometers, as well as the molecular scintists providing the biological samples.

Major tasks include

  • the main subject will be to develop, implement and experimentally apply a microfluidic platform that enables spatio-temporal control of microfluidic-chamber/cuvette flow through systems (microfluidic chips) and its integration with laser-based field-resolved spectroscopy;
  • setting up simple (optical) measurement setups;
  • writing and presenting the results of scientific work;
  • identification and establishment of potential collaborations that can help in the above-mentioned tasks

Required qualifications and skills:

  • doctoral degree (or equivalent) in microfluidics, microengineering, physics, biology or chemistry or related fields;
  • experience with microfluidic engineering;
  • experience in setup and adjustment of optical systems;
  • ability to work in an international environment;
  • user-level computer management skills;
  • strong motivaton, ability to work independently but also well equipped for collaboration in this multidisciplinary project;
  • ability to quickly adapt to a changing environment;
  • team spirited and like to share your scientific issues with a multicultural and diverse environment;
  • quick learning and good communication skills, excellence in expressing in English, both orally and in written form, command of German and / or Hungarian is advantageous;
  • excellent planning skills, with responsibile mindset while keeping high level of flexibility and accuracy.

We offer:

  • a unique possibility to work at highly cross-disciplinary field, at the forefront of laser sciences shaping the future of biomedical diagnostics;
  • a broad range of activities in a dynamically evolving second-to-none endeavor and professional environment;
  • ample opportunities for improving professional skills and qualifications – including professional training and workshops;
  • the position is initially limited to two years with the possibility of an extension

We are interested in filling the positions as soon as possible, thus the applications are continuously evaluated until the position is filled.

Please send a brief cover letter explaining your interest in the post and your CV and contact information of two references to Dr. Mihaela Zigman (mihaela.zigman@lmu.de).

Contact

Center for Molecular Fingerprinting (CMF)
Molekuláris- Ujjlenyomat Kutató Közhasznú Nonprofit Kft.

1093 Budapest, Czuczor utca 2-10. 2nd floor, Hungary
Phone: +36 30 0123 535
Email: info@mukkozpont.hu