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Scientific
Mission

Artist´s view of CMF (© Dennis Luck)

The molecular composition of systemic biofluids of living organisms is a sensitive indicator of their physiological states, useful for disease detection. The capability of observing signatures of miniscule changes in concentration of a wide variety of molecules of liquid biopsies (blood plasma and serum) is thus crucial for advancing systems biology and medical diagnostics.

Molecules of naïve organic samples are illuminated by ultrashort laser pulses. The abruptly excited molecules emit light at characteristic frequencies in the wake of the excitation. The electric field of this molecular signal is detected with femtosecond-attosecond resolution by using world-leading ultrafast laser technology. The new approach – field-resolved laser molecular fingerprinting – suits for detecting simultaneous, correlated changes in concentration of a wide variety of molecules across all types relevant to biological systems: proteins, lipids, carbohydrates, and amino acids. The resultant molecular fingerprint holds promise, possibly in combination with other biomarking approaches, for improving the specificity and sensitivity of molecular disease detection.

CMF pursues the development, testing and validation of laser molecular fingerprinting for next-generation blood-based diagnostics with large-scale clinical samplings in cooperation with major health-care institutions in Hungary and abroad. This mission is driven by the vision of a reliable, cost-effective, high-throughput approach for:

  • populational health monitoring,
  • disease detection.

The initial focus is on detection of cancer and cardio-vascular disease conditions. To this end, an international collaborative network of clinical and research centers is being established. Long-term preservation of the invaluable blood samples collected for the above goals will be performed at cryogenic conditions in a dedicated CMF biobank. Standardized workflows are used for sample collection as well as for secure collection and management of harmonized clinical information in a database system designed for handling big data, among a highly professional quality control system with an overall thorough adherence to the GDPR provisions. Machine learning algorithms will be applied for sample classification based on their laser molecular fingerprints and established biomarkers.


The aim

Development of laser molecular fingerprinting for next-generation molecular diagnostics of blood, aiming at health monitoring and disease detection.

How?

A drop of blood plasma is exposed to ultrashort laser light and the light waves emitted by the excited molecules of the sample are directly detected with femtosecond-attosecond laser techniques.

Funded by

Hungarian Ministry of Innovation and Technology.

News

(© Thorsten Naeser)
March 15, 2021
Take it personally: A new blood-based test for monitoring health

A new study carried out by a team of laser physicists, molecular biologists and physicians has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals.

March 15, 2021
Taking it personally: A new blood-based test for monitoring health

A new study carried out by a team of laser physicists, molecular biologists and physicians based at LMU Munich and the Max Planck Institute for Quantum Optics has confirmed the temporal stability of the molecular composition of blood in a population of healthy individuals. The data provide a basis for a new method of monitoring the constituents of blood and detecting alterations that reveal changes in a person’s state of health.

The molecular composition of the blood provides information regarding one’s state of health, and may be compared to an individual fingerprint. In principle, changes in the constituents of blood can serve as early signs of disease. However, before chemical fingerprints can be utilized for diagnostic purposes, the stability of the molecular patterns in healthy persons over time must be firmly established. Researchers under the direction of Dr. Mihaela Žigman, Head of the Broadband Infrared Diagnostics (BIRD) group in the Department of Laser Physics led by Prof. Ferenc Krausz at LMU Munich, in collaboration with Prof. Dr. Nadia Harbeck at the LMU Medical Centre, have now successfully accomplished this task. With the aid of a method known as Fourier-transform infrared spectroscopy (FTIR), the team has shown that the molecular composition of blood samples obtained from a cohort of healthy donors remains stable over a period of several months, and confirmed that each of the resulting spectra could be clearly assigned to an individual person.

Rapid diagnosis of human diseases is a long standing problem in medicine. As diseases often alter the molecular make-up of circulating body fluids, obtaining a snapshot of their molecular composition would be invaluable in detecting a multitude of diseased states, and the types and concentrations of the many molecules found in the bloodstream can provide vital information on a person’s health. The real challenge, however, comes when one tries to determine the exact composition of body fluids, given that the concentrations of informative molecules are often extremely low. The interdisciplinary BIRD team led by Dr. Mihaela Žigman in Prof. Dr. Ferenc Krausz’s department at LMU, in collaboration with Prof. Dr. Nadia Harbeck at the LMU Medical Centre, has now investigated the stability of the chemical make-up of blood samples over days, weeks and even months.
Based on Fourier-transform infrared measurements (FTIR), the researchers analysed the molecular fingerprints of serum and plasma samples obtained from 31 healthy individuals over the clinically relevant period of 6 months. The study demonstrated that the infrared molecular fingerprint of each individual donor in fact remained stable over periods ranging from a few days to weeks and months, and each temporal profile could be readily attributed to the participant concerned.
“This newly revealed temporal stability of blood-based infrared fingerprints provides a basis for future applications of minimally invasive infrared spectroscopy as a reliable method for the future of health monitoring,” says Mihaela Žigman, leader of the research group.
Standard Fourier-transform infrared spectroscopy, which uses conventional light sources, could soon be replaced by chemical analyses based on infrared lasers. Given the much higher intensity of laser light, the latter method should be more sensitive and precise, and should therefore yield more detailed and informative characterizations of the molecular constituents of blood. The physicists in the attoworld team, led by Prof. Ferenc Krausz, are now working on the laser technologies necessary to achieve this aim. Exposure to intense infrared light causes molecules to vibrate and emit light at specific frequencies, which depend on the chemical structures of the molecules within the sample. Analysis of the components of the resulting spectrum of electromagnetic oscillations enables researchers to assign them to the many types of molecules present in body fluids. As Prof. Krausz and colleagues reported last year, the new method allows minuscule amounts of different classes of molecules to be spectroscopically detected (Nature, 2. January 2020; doi 10.1038/s41586-019-1850-7).
“With our lasers, we can already detect electrical signals emitted by excited molecules with very high sensitivity,” Ferenc Krausz explains. “Such precise measurements of alterations in the molecular composition of body fluids, together with knowledge of the stable molecular fingerprint of healthy controls, opens up new analytical opportunities in biology and medicine,” says Marinus Huber, leading author of the study. “Our results reveal that it is possible to obtain informative, blood-based infrared fingerprints efficiently, repeatedly and in a minimally invasive manner. The key, in this case, is that the analysis ought to be sensitive enough and sufficiently broad to cover a wide range of possible molecules (or types of molecules) - to be in position to monitor personal health and detect disorders at an early stage. Practically speaking, following-up a person’s health status regularly might become paramount for timely-detecting relevant deviations. In addition to its uses in the fields of health monitoring and preventive medicine, systems biology shall also benefit from the availability of the approach,” Mihaela Žigman adds.
-Thorsten Naeser

Original Publication:
Huber, M., Kepesidis, K.V., Voronina, L. et al. Stability of person-specific blood-based infrared molecular fingerprints opens up prospects for health monitoring. Nat Commun 12, 1511 (2021).

https://doi.org/10.1038/s41467-021-21668-5
https://www.nature.com/articles/s41467-021-21668-5
Further information is available from:
Dr. Mihaela Žigman
Ludwig-Maximilians-University Munich
Am Coulombwall 1
85748 Garching, Germany.
E-Mail: zigman@mukkozpont.hu.

November 4, 2020
Let there be light: Laser Development and Technology Team forms at CMF

When it comes to disease detection and health monitoring with field-resolved molecular fingerprinting, turning our vision into reality requires dedicated technological development at the forefront of our scientific research.

November 4, 2020
Let there be light: Laser Development and Technology Team forms at CMF

When it comes to disease detection and health monitoring with field-resolved molecular fingerprinting, turning our vision into reality requires dedicated technological development at the forefront of our scientific research. It starts from the development of new mid-infrared laser sources via advancing sample handling and detection technologies and goes toward finding optimal data acquisition and processing strategies. Over the last couple of months, a new team has formed at CMF with the particular goal to tackle these technical and scientific challenges. In close collaboration, the CMF laser development and technology team in Garching (Germany) is joining forces with LMU laser scientists to combine all technological advances in a one of a kind prototype device for molecular fingerprinting. Once the laser laboratory of CMF will open its gates in Budapest, this instrument will be fundamental to be used in blood sample analysis. Currently, the CMF team headed by Dr. Alexander Weigel is moving frontiers in laser development and solving experimental challenges towards that end.

October 28, 2020
Strengthening the team: Viola Zoka

We would like to wish a warm welcome to a new colleague: Since October 2020, the research group around Dr. Mihaela Žigman has been supported by Viola Zóka, a new medical-technical assistant!

October 28, 2020
Strengthening the team: Viola Zoka

We would like to wish a warm welcome to a new colleague: Since October 2020, the research group around Dr. Mihaela Žigman has been supported by Viola Zóka, a new medical-technical assistant!

The young Hungarian completed Bachelor of Science in Chemistry. She had developed her passion for chemistry early on and intensified it by her professional experience in a laboratory in Nagykanizsa, Hidrofilt Ltd. Hungary, where she performed analytical chemistry of water samples. When Viola heard about newly developing infrared molecular fingerprinting to analyze way more complex human blood samples that she was used to, she applied for a job at the Center for Molecular Fingerprinting (CMF). CMF is strongly collaborating with the Laser Physics department of the Ludwig Maximilians University (LMU) Munich and prior to having its own laboratories built and established in Hungary, the samples from the clinical studies lead by CMF will be analyzed at the LMU. And Viola made a move from Hungary to Germany to start her new professional life at the Garching Research Center and directly fuel the CMF research goals from there. Together with laser scientist and molecular biologists, Viola will analyze blood samples for their molecular composition using infrared spectroscopy - something that everyone is very much excited about!

March 11, 2020
Sample storage at its best

CMF’s strategic partner, the Ludwig-Maximilians-University (LMU) in Munich, Germany, just installed an automated biobanking system for…

March 11, 2020
Sample storage at its best

CMF’s strategic partner, the Ludwig-Maximilians-University (LMU) in Munich, Germany, just installed an automated biobanking system for sample storage at temperatures below minus 150°C. What is this good for? Under these very low temperatures - so called “cryogenic” conditions in the atmosphere above liquid nitrogen - human samples, such as blood plasma or actually any biological tissues, can be kept for several years, decades without sample deterioration. It assures that valuable human materials collected in frame of clinical studies can be used in long term and thus enables researchers to analyze these with molecular fingerprinting techniques most efficiently. Such an automated cryogenic system is made of large tightly sealed tank that is capable to store up to 60,000 samples. The system is further equipped with a robotic arm that can pick individual tubes automatically, such that the samples are kept and handled well below minus 100 °C at all times.

This installation has a direct impact for the future of the joint CMF-LMU research aims. On the one hand the two institutions will be conducting joint clinical studies. On the other, LMU biobanking system also serves as a test case for the CMF’s envisioned own biorepository, to be established in Budapest.

Thus, CMF is getting familiar with the best way to store most valuable biological materials for the years of research to come!

January 07, 2020
Field-resolved infrared spectroscopy of biological systems

In cooperation between the Laboratory of Attosecond Physics at the Max Planck Institute of Quantum Optics…

January 07, 2020
Field-resolved infrared spectroscopy of biological systems

In cooperation between the Laboratory of Attosecond Physics at the Max Planck Institute of Quantum Optics and the Centre for Advanced Laser Applications of the Ludwig-Maximilians-Universität München, the King Saud University Riad and the Center for Molecular Fingerprinting (Budapest, Hungary), we have developed a molecular spectroscopy technique that overcomes long-standing limitations of traditional techniques, like Fourier-transform infrared spectroscopy, as described in our recent publication. A powerful femtosecond laser delivers 28 million pulses per second, with highly repeatable waveforms, comprising merely a few infrared-electric-field oscillations. Transmitting these pulses through a complex, molecular sample synchronously excites infrared-active vibrations of molecular bonds, each at its own eigenfrequency. The signals emitted by the vibrationally-excited molecules in the wake of the impulsive excitation coherently add up to a ‘molecular fingerprint’ characteristic of the sample’s molecular composition.

In contrast to traditional spectroscopies, where the entire response of the sample to an infrared excitation hits the detector(s), in field-resolved spectroscopy sub-optical-cycle portions of the time-domain fingerprint field are sequentially carved out by means of nonlinear optics. This dramatically reduces any infrared background on the measured signals, including the noise originating from the excitation and thermal background. This conceptional advance results in an unprecedented detection sensitivity and dynamic range.

We have also demonstrated first biological applications that have so far been beyond the reach of infrared vibrational spectroscopies. These applications include first high-signal-to-noise ratio infrared transmission measurements of living biological tissue and fingerprinting of liquid biopsies with sub-µg/ml sensitivity. Thus, field-resolved spectroscopy promises improved molecular sensitivity and molecular coverage for probing complex, real-world biological and medical settings.

December 16th, 2019
Honorary membership for Prof. Krausz

Prof. Ferenc Krausz has recieved the honorary membership of the Roland Eötvös Physical Society, Budapest. After…

December 16th, 2019
Honorary membership for Prof. Krausz

Prof. Ferenc Krausz has recieved the honorary membership of the Roland Eötvös Physical Society, Budapest. After receiving the membership the laser physicist of the Ludwig-Maximilians University München and the Max-Planck-Institute of Quantum Optics held an lecture about how attosecond science technologies can in the future contribute to a new way of finding molecules in human biofluids like blood. This may path the way for medical applications to detect diseases by analyzing so called molecular fingerprints with the help of strong laser light pulses.

            Team

Prof. Dr. Ferenc Krausz

Scientific Director, CEO

krausz@cmf.science

László Vastag, MD

Managing Director

vastag@mukkozpont.hu

Dr. Mihaela Žigman

Research Director

zigman@mukkozpont.hu

Dr. Frank Fleischmann

Advisor – Biological Laboratories

fleischmann@mukkozpont.hu

Eszter Tuboly PhD

Biobank Manager

tuboly@mukkozpont.hu

Márton Görög

Leader Data Scientist

gorog@mukkozpont.hu

Viola Zóka

Medical technical assistant

zoka@mukkozpont.hu

Zsuzsa Uti

L4L Project Coordinator

uti@mukkozpont.hu

Dr. Alexander Weigel

Chief Laser Scientist

weigel@mukkozpont.hu

Patrik Karandušovský

Computer Scientist

karandusovsky@mukkozpont.hu

Aleksandar Sebesta

Laser Engineer

sebesta@mukkozpont.hu

Maciej Kowalczyk

Laser Scientist

kowalczyk@mukkozpont.hu

Shizhen Qu

Laser Scientist

qu@mukkozpont.hu

Christina Hofer

Nonlinear Optics Scientist

hofer@mukkozpont.hu

Partners

(© Thorsten Naeser)

CMF seeks extending the above network of long-term strategic partners with clinical centers and other healthcare providers across Hungary and abroad for the pursuit of its mission.

            Join us

Individuals interested in joining a highly-motivated team dedicated to the pursuit of the grand goals of CMF are invited to apply for the following open positions:

Március 31, 2021

Minőségbiztosítási menedzser

Minőségbiztosítási szakemberként lehetősége van csatlakozni egy olyan csapathoz, ahol világhírű kutatók által kezdeményezett, úttörő jelentőségű kutatás folyik neves hazai és nemzetközi tudományos partnerek bevonásával.

Feladatok:

  • A minőségügyi rendszer és a teljes dokumentációs hátterének létrehozása és fejlesztése az ISO 9001 szabvány szerint;
  • Az említett QM rendszer karbantartása és folyamatos fejlesztése;
  • Szabályzatok előkészítésének támogatása, SOP írása és rendszeres felülvizsgálata, hozzájárulás a tudományos és kutatási jelentések készítéséhez;
  • Minőségbiztosítási dokumentáció adminisztrációja, valamint irattárolási és archiválási tevékenységek végzése;
  • Belső rendszerek és külső partnerek tevékenységeinek a kialakított minőségbiztosítási rendszerekkel való megfelelőségének és megfelelésének biztosítása;
  • Adminisztratív és technikai támogatás nyújtása orvostechnikai eszközökre és labor akkreditációra vonatkozó előírások betartásának biztosítása érdekében;
  • Szoros együttműködés a kutatási és klinikai projektmenedzsmenttel a kutatási eredmények minőségének és időben történő találkozásának biztosítása érdekében, ideértve a klinikai SOP-k fejlesztését és rendszeres felülvizsgálatát;
  • Belső ellenőrzések tervezése és végrehajtása, valamint teljes együttműködés a külső auditorokkal és ellenőrökkel;
  • Belső és külső személyzet, szállítók és beszállítók minőségi és rendszerekkel kapcsolatos képzésének tervezése és lebonyolítása, képzési tanúsítványok kiadása és felügyelete.

Elvárásaink:

  • Minimum 2-3 éves minőségügyi tapasztalat megléte, ezen belül legalább 1 év releváns tapasztalat az élettudományok valamely területén;
  • Főiskolai vagy egyetemi végzettség megléte élettudományokból, orvostudományból, gyógyszerészetből vagy egy kapcsolódó tudományos területen (vagy ezzel egyenértékű szakmai tapasztalat)
  • Folyékony írásbeli és kiváló verbális kommunikációs készség szükséges magyar és angol nyelven;
  • Tapasztalat a minőségbiztosítási rendszerek, az SOP-k és a munkautasítások fejlesztésében;
  • ISO 9001 és ISO 13485 alapos ismerete, a termékek validálásának ismerete;
  • Magabiztos MS Office programismeret;
  • Precíz, pontos, önálló munkavégzés;
  • Megbízhatóság, terhelhetőség, problémamegoldó képesség;
  • Proaktív, lojális személyiség;
  • Nyitott, kommunikatív, dinamikus hozzáállás.

Amit kínálunk:

  • Változatos és felelősségteljes feladatokat;
  • Versenyképes juttatási csomagot;
  • Nemzetközi környezetben való munkavégzést;
  • Szakmai fejlődési lehetőséget;
  • Megoldás-orientált légkört és egy dinamikusan fejlődő szervezetben.

Várjuk jelentkezését, melyben kérjük küldje el szakmai önéletrajzát csatolva Márton-Szűcs Eszter (martonszucs@mukkozpont.hu) részére.

Március 31, 2021

Communications Manager

We are seeking a Communications Manager to build a strong network, increase awareness and develop an enviable corporate image by developing and managing effective communication and media relations programs.

Responsibilities:

  • Coordinating all public relations activities;
  • Developing a marketing communications plan including strategy, goals, budget and tactics;
  • Developing a media relations strategy, seeking high-level placements in print, broadcast and online media;
  • Coordinating social media to engage audiences across traditional and new media;
  • Managing media inquiries and interview requests;
  • Being responsible for continuously creating content for the company’s website, press releases, byline articles and presentations;
  • Monitoring, analyzing and communicating PR results on a quarterly basis;
  • Building relationships to grow industry awareness;
  • Manage the visibility and awareness of the company’s external and internal communication activities externally, inside the company, and toward international corporate communications;
  • Coordination, planning, and execution of internal communication and company culture materials and actions;
  • Contribute to projects of other departments from communication point of view;
  • Managing relationship with different agencies.

Requirements:

  • Proven working experience in public relations required;
  • Proven track record designing and executing successful public relations campaigns at the national level;
  • 3-5 years of experience in Communications and Marketing;
  • BA/MA degree in Marketing, Advertising, Communications or a related discipline;
  • Strong relationships with both local and national media outlets;
  • Knowledge and experiences of digital marketing tools;
  • Experience in acting as a company spokesperson; comfortable and skilled in both broadcast and print media interviews;
  • Exceptional written and verbal skills both in Hungarian and English;
  • Solid experience with social media including blogs, Facebook, Twitter, etc.;
  • Event planning experience;
  • Paid social campaigns experience;

Top personal skills & proficiencies:

  • Being a team player with a high degree of initiative, goal orientation, and organizational skills;
  • Strategic and flexible mindset;
  • Ability to work on multiple tasks in parallel;
  • Strong motivation, ability to work independently but also well equipped for collaboration in this multidisciplinary project;
  • Team-spirited and like to share your wide range of ideas with a multicultural and diverse environment;
  • Strongly developed, sophisticated written and verbal communication skills

Strong plus:

  • Enthusiasm for scientific topics;
  • Experience in working with professionals in the fields of exhibition design, graphics as well as experience with the use of film and new media in exhibitions;
  • Experience in science journalism;
  • Editorial experience;
  • NKOH experience.

What we are offering:

  • Diverse and responsible tasks;
  • Competitive benefit package;
  • Working in an international environment;
  • Professional development opportunities;
  • Solution-oriented atmosphere and a dynamically evolving organization.

If you are looking for an exciting challenge in an international and interdisciplinary environment at the forefront of cutting-edge research, please send your professional CV to Eszter Márton-Szűcs (martonszucs@mukkozpont.hu).

31st March, 2021

Postdoc: Physicist with Background in Nonlinear Optics

At the Center for Molecular Fingerprinting, we combine cutting-edge femtosecond laser technologies with novel molecular fingerprinting techniques to advance a new type of mid-infrared spectroscopy on the electric-field level. The novel systems are developed and utilized by a highly interdisciplinary team of physicists, data scientists, biologists and clinical personal to identify, via minuscule variations in the infrared response, medical conditions such as cancer in body liquid samples.

The successful candidate will work together with scientists and technicians at the CMF and the Joint LMU-MPQ Laboratory for Attosecond Physics in Garching, Germany to develop next-generation instruments based on bright, coherent, broadband mid-Infrared sources and field-resolved detection. The goal for this position is to develop coherent field-resolved infrared metrology with multi-octave spectral coverage and unprecedented detection sensitivity. The duration of the position is initially 2 years, with the possibility of extension. For the first two years the place of work will be predominantly at the LAP in Garching, Germany.

Responsibilities:

  • Development of electric-field-resolved mid-infrared metrology
  • Reaching unprecedented spectral bandwidth and sensitivity with coherent mid-IR detection
  • Development of the detection technology for the next-generation instruments for large-scale health monitoring and desease detection with mid-infrared fingerprinting
  • Presentation and publication of scientific output

Qualifications and Skills:

  • PhD in physics or a related discipline
  • Experience with ultrafast lasers and nonlinear optics
  • Ideally, experience with infrared and/or nonlinear spectroscopies
  • Ideally, experience signal processing and programming (for example with Labview)
  • Interest in interdisciplinary work with interface to biomedical applications
  • Good command of the English language

What we can offer:

  • full-time semi office-based job
  • competitive salary & benefits
  • motivated local and international team
  • development opportunity

Please send a brief cover letter explaining your interest in the position, your CV and contact information of two references to Dr. Alexander Weigel (weigel@mukkozpont.hu).

31st March, 2021

Electrical Engineer

At the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) we combine cutting-edge femtosecond laser technologies [1-3] with novel molecular fingerprinting techniques [4,5] to advance a new type of mid-infrared spectroscopy on the electric-field level. The novel systems are developed and utilized by a highly interdisciplinary team of physicists, data scientists, biologists and clinical personal to identify, via minuscule variations in the infrared response, medical conditions such as cancer in body liquid samples.

The successful candidate will work together with scientists and technicians at the CMF and the Joint LMU-MPQ Laboratory for Attosecond Physics (LAP, attoworld.de) in Garching (Germany) to develop next-generation instruments of laser-based instrumentation for field-resolved detection. The goal for this position is to optimize photodetection, to precisely synchronize and stabilize multiple pulsed lasers, and signal acquisition with suitable microwave electronics. The duration of the position is initially 2 years, with the possibility of extension. For the first two years the place of work will be predominantly at the LAP in Garching (Germany).

Tasks:

  • Identify and implement low-noise, high-dynamic range photodection solutions for our instruments
  • Develop precise feedback loops for synchronization and stabilization of pulsed lasers
  • Generate and modify microwave signals for clocking low-noise, high-speed data acquisition
  • Develop the electric/electronic backbone for laser-based instrument prototypes.

Qualifications and Skills:

  • Master’s degree or equivalent in electrical engineering or a related technical discipline
  • Experience with ultra-sensitive photodetection, and minimizing detection noise
  • Experience with electronic signal generation and synchronization including PLLs
  • Experience with handling electrical signals in the microwave regime
  • Ideally, experience with FPGA programming
  • Interest in interdisciplinary work with interface to bio-medical applications
  • Good command of the English language
  • German language skills are advantageous

Please send a brief cover letter explaining your interest in the position, your CV and contact information of two references to Dr. Alexander Weigel (weigel@cmf.science).

[1] J. Zhang et al., Light Sci. Appl. 7, 17180 (2018).
[2] Q. Wang et al., Opt. Letters 44, 2566 (2019).
[3] N. Nagl et al., Opt. Letters 44, 2390 (2019).
[4] I. Pupeza et al., Nature Photon. 9, 721 (2015).
[5] I. Pupeza et al., Nature 577, 52 (2020).

31st March, 2021

Laser Engineer

At the Center for Molecular Fingerprinting (CMF, mukkozpont.hu) we combine cutting-edge femtosecond laser technologies [1-3] with novel molecular fingerprinting techniques [4,5] to advance a new type of mid-infrared spectroscopy on the electric-field level. The novel systems are developed and utilized by a highly interdisciplinary team of physicists, data scientists, biologists and clinical personal to identify, via minuscule variations in the infrared response, medical conditions such as cancer in body liquid samples.

The successful candidate will work together with scientists and technicians at the CMF and the Joint LMU-MPQ Laboratory for Attosecond Physics (LAP, attoworld.de) in Garching (Germany) to develop next-generation instruments based on bright, coherent, broadband mid-Infrared sources and field-resolved detection. The goal for this position is to transform latest research results into a technically mature and reliable laser-based measurement system with unprecedented performance. The duration of the position is initially 2 years, with the possibility of extension. For the first two years the place of work will be predominantly at the LAP in Garching (Germany).

Tasks:

  • Development of laser system prototypes (including laser oscillators, amplifiers, compressors, conversion and detection modules), based on exiting research setups
  • Technical improvement of the laser systems to optimize for example stability, noise performance and user friendliness
  • Test and characterize laser and downstream module specifications and resolve potential problems
  • Instruct new team members in the usage of the laser and measurement systems

Qualifications and Skills:

  • Master’s degree or higher in physics or a related technical discipline
  • Experience with the setup and adjustment of optical systems
  • Strong self-motivation and the ability to solve problems independently
  • Experience with computer-aided technical drawings (e.g., Autodesk Inventor)
  • Ideally, experience with Labview, Python, or another programming language
  • Interest in interdisciplinary work with interface to bio-medical applications
  • Good command of the English language
  • German language skills are advantageous

Please send a brief cover letter explaining your interest in the position, your CV and contact information of two references to Dr. Alexander Weigel (weigel@cmf.science).

[1] J. Zhang et al., Light Sci. Appl. 7, 17180 (2018).
[2] Q. Wang et al., Opt. Letters 44, 2566 (2019).
[3] N. Nagl et al., Opt. Letters 44, 2390 (2019).
[4] I. Pupeza et al., Nature Photon. 9, 721 (2015).
[5] I. Pupeza et al., Nature 577, 52 (2020).

31st March, 2021

Laser Technician

Lasers4Life (L4L) is a collaborative venture involving laser physicists, mathematicians, physicians and molecular biologists based at Ludwig-Maximilians-Universität (LMU) in Munich and the Center for Molecular Fingerprinting (CMF), Budapest, Hungary (http://www.cmf.science). The consortium provides a translational bridge between laser physics and clinical sciences. Its central goal is to demonstrate how a unique laser technology that generates ultrashort light pulses can be utilized for the early detection of diseases such as cancers. For more details visit: https://www.lasers4life.de/

Blood samples are collected within clinical trials with the aim of cancer detection via infrared spectroscopic analysis. Clinical studies for cancer detection suggest that the approach carries high potential with wide societal impact, already at the early stage of development. For further development, larger clinical studies are carried out to acquire human blood samples for analysis. We are seeking a suitable candidate for filling the position of a Laser Technician for the operation and maintenance of our ultrashort pulsed lasers systems used for routine infrared spectroscopic analysis of human blood samples.

The advertised position will be located at the Laboratory for Extreme Photonics (LEX photonics; www.lex-photonics.de) of the University of Munich at the research campus Garching, north of Munich. The candidate will work in a highly international and interdisciplinary team in direct collaboration with laser engineers, developing the next generation of our laser-based infrared spectrometers, as well as the bio-laboratory, which provides the samples and supports their analysis.

Major tasks include:

  • Routine operation of our laser-based infrared spectrometers, consisting of femtosecond-laser oscillators, amplifiers, pulse compressors and electro-optical detection systems;
  • Regular quality control and documentation of the achieved laser parameters;
  • Maintenance and fine adjustment of optomechanical components as well as implementation of improvements of the laser systems;
  • Facilitating the routine analysis of clinical sample;
  • Instruct new team members on how to use the laser spectrometer;
  • Elaboration of SOPs for laser operation in cooperation with biomedical staff

Required qualifications and skills:

  • Bachelor degree (or equivalent) in physics, physical engineering or electrical engineering or related fields;
  • Rood command of English (written and spoken) is a pre-required, command of German and / or Hungarian is advantageous;
  • RAbility to work in an international environment;
  • RUser-level computer management skills;
  • RQuick learning and good communication skills;
  • RSelf-employment after training;
  • Responsibility

We offer:

  • a broad range of activities in a dynamically evolving second-to-none endeavour and professional environment;
  • ample opportunities for improving professional skills and qualifications – including professional trainings and workshops;
  • salary based on the German public service (TVL), the contracting will be via CMF according to Hungarian labour legislation.
  • the position is initially limited to two years with the possibility of an extension

We are interested in filling the positions as soon as possible and applications are continuously evaluated until the position is filled.

Please send a brief cover letter explaining your interest in the post and your CV to Dr. Mihaela Zigman (zigman@mukkozpont.hu) and Marinus Huber (huber.marinus@physik.uni-muenchen.de).

Contact

Center for Molecular Fingerprinting (CMF)
Molekuláris- Ujjlenyomat Kutató Közhasznú Nonprofit Kft.

1093 Budapest, Czuczor utca 2-10. 2nd floor, Hungary
Phone: +36 30 0123 535
Email: info@mukkozpont.hu